The Advisory Committee on Immunization Practices (ACIP) is facing severe difficulties following a significant round of layoffs at the US Centers for Disease Control and Prevention (CDC). Critics argue that these changes, instigated by RFK Jr, are putting vaccine development and guidance at risk. Key working groups within the committee have not met for months, and communication from staff was scarce even prior to receiving reduction in force notices. The layoffs and lack of communication have raised concerns about the future of vaccine development and guidance.